The international, randomised phase III MONALEESA-7 trial found that adding ribociclib to standard-of-care endocrine therapy significantly improved overall survival for premenopausal women with advanced HR-positive/HER2-negative breast cancer compared with endocrine therapy alone. After 42 months of follow-up, the survival rate was 70% for women who took the combination therapy compared with 46% for women who

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Study finds engaging young children in conversation is more important for brain development than “dumping words” on them. A landmark 1995 study found that children from higher-income families hear about 30 million more words during their first three years of life than children from lower-income families. This “30-million-word gap” correlates with significant differences in tests

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Utilising a cell’s own molecular delivery system could enable specific biomedical treatments In the world of drug delivery, getting an active compound to the right tissue or organ before the body’s defences break it down can make the difference between wellbeing and sickness, life and death. Clever capsules and coatings can boost the drug effect

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Walking as few as 4400 steps per day may decrease the risk for all-cause mortality among older women, according to a study published online today in JAMA Internal Medicine and presented simultaneously at the American College of Sports Medicine (ACSM) 2019 Annual Meeting. The risk for death fell with increasing number of steps per day, and these benefits leveled

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Cancer drugs are being approved by the FDA at an alarmingly fast rate after preliminary studies show encouraging results. However, after more careful follow-up trials were done, most of these drugs did not show any clear benefits. Cancer drugs are usually granted accelerated approval in the hopes of providing patients faster access to medicine that

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Transaction allows Santhera to advance its long-term growth strategy by focusing on the development of its clinical-stage neuromuscular and pulmonary programs Santhera Pharmaceuticals announces that it has entered into an exclusive license agreement with Chiesi Farmaceutici, an international researchfocused healthcare group (Chiesi Group), under which Chiesi Group will in-license Raxone® for the treatment of LHON

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Boston University neuroscientist shows that stimulating different parts of the brain can dial up or down a specific memory’s emotional oomph What if scientists could manipulate your brain so that a traumatic memory lost its emotional power over your psyche? Steve Ramirez (CAS’10), a Boston University neuroscientist fascinated by memory, believes that a small structure in the

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For thousand of years humans have been using fermentation as a way of preserving foods and engendering good gut health. A fascinating new study from scientists at the University of Leipzig has discovered that a specific immune function receptor, uniquely evolved in humans and great apes, is triggered by a metabolite from lactic acid bacteria

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Whether hippocampal neurogenesis persists throughout life in the human brain is not fully resolved. Researchers of the Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA demonstrate in a just published paper on Cell Stem Cell that hippocampal neurogenesis is persistent through the tenth decade of life and is detectable

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Meaningful studies are lacking for certain patient groups / Disease-specific registries could help close the data gap The German Institute for Quality and Efficiency in Health Care (IQWiG) has investigated whether patients suffering from non-Hodgkin lymphoma have (better) chances of recovery when stem cells from another person are transplanted. In its final report now presented,

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