A Single-Cell analysis on blood antigen-presenting cells in severe COVID-19 shows induced Antiviral Immunity Defects

A number of antiviral immune defenses are compromised among people who develop severe COVID-19, a new single-cell RNA sequencing analysis has found. Some people infected with SARS-CoV-2 develop severe disease marked by acute respiratory failure and possibly sepsis and death. While studies have highlighted the possible role of systemic inflammatory responses in severe COVID-19, the

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Towards Understanding AstraZeneca Vaccine-induced Immune Thrombotic Thrombocytopenia (VITT)

A German researcher thinks he knows what has caused some people to develop blood clots after receiving coronavirus vaccines. University of Greifswald hematologist Andreas Greinacher believes the reaction is linked to EDTA, a preservative found in the AstraZeneca vaccine. The AstraZeneca vaccine contains more than 1,000 proteins that have been derived from human proteins —

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33% can be the proportion of SARS-CoV-2 Infections That Are Asymptomatic for a Systematic Review

In the 14 studies with longitudinal data that reported information on the evolution of symptomatic status, nearly three quarters of persons who tested positive but had no symptoms at the time of testing remainedasymptomatic. Current data suggest that infected persons without symptoms—including both presymptomatic and asymptomatic persons—account for more than 40% of all SARS-CoV-2 transmission.

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Oxford AstraZeneca vaccine could be approved in UK in the next weeks

he game-changing Oxford vaccination could get the go-ahead “just after Christmas”, a leading expert has said . John Bell, Regius Professor of Medicine at Oxford University, stressed the data behind the jab is looking “better than ever”. The Medicines and Healthcare products Regulatory Agency is examining the vaccine developed by Oxford University and pharmaceutical giant AstraZeneca. With an announcement from the MHRA eagerly anticipated, Prof Bell told

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Wyss Institute researchers demonstrate machine-guided engineering of AAV capsids for gene therapy

High-throughput synthetic biology approach reveals hidden AAV features and could help fast-track future gene therapies Adeno-associated viruses (AAVs) have become the go-to vehicle for delivering therapeutic gene cargo to target tissues for the wave of gene therapies that are in development in academic and biotechnology laboratories. However, natural AAVs do not specifically target diseased cells

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nAngioDerm: European Grant for 3D Printed Skin and Wound Care

The regenerative medicine project nAngioDerm has received a European grant of €747,000 ($822,000) to provide a solution for dermal regeneration, by helping patients whose wounds from ulcers or major burns fail to heal. The funding will go to five European institutions and companies collaborating on the project, which is coordinated by the Institute for Bioengineering of

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Laser printing tech produces graphene waterproof e-textiles in minutes

The next generation of waterproof smart fabrics will be laser printed and made in minutes. That’s the future imagined by the researchers behind new e-textile technology. Scientists from RMIT have developed a cost-efficient and scaleable method for rapidly fabricating textiles that are embedded with energy storage devices. In just three minutes, the method can produce

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