REGENERATIVE MEDICINE – Page 9 – REGENHEALTHSOLUTIONS (RHS)

PIER MARIA FORNASARI
2022-08-09

Higher doses of CAR T cell therapy associate with improved outcomes in young patients with B-ALL : a report from the pediatric real-world CAR consortium

Young people who received doses of tisagenlecleucel, a chimeric antigen receptor T cell (CAR-T) therapy, at the higher end of the FDA-approved dosing range had significantly better survival rates at one year compared with those who received lower doses within this range, according to research published today in Blood Advances. Since its approval as the first

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PIER MARIA FORNASARI
2022-08-06

St. Jude Researchers improved CAR T-cell therapy for T-cell acute lymphoblastic leukemia

Scientists at St. Jude Children’s Research Hospital developed a simple method to select for more effective cancer-destroying CAR T cells for patients with relapsed T-ALL. Scientists at St. Jude Children’s Research Hospital are improving chimeric antigen receptor (CAR) T-cell therapy. Their new simplified approach selected for an advantageous T-cell type and showed promise in the lab against relapsed T-cell

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PIER MARIA FORNASARI
2022-08-03

Gene Therapy Approach Shows Promise in Treating ALS

In rodent models, introduced neuroprotective protein slowed disease progression and increased life span Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control. In a new study, published July 11, 2022 in the journal Theranostics, researchers at

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PIER MARIA FORNASARI
2022-08-01

Progress toward a stem cell–based therapy for blindness

A multi-institutional effort led by researchers at the School of Veterinary Medicine is taking steps to develop an effective technique to regenerate photoreceptors cells and restore sight in people with vision disorders. What if, in people with blinding retinal disorders, one could simply introduce into the retina healthy photoreceptor cells derived in a dish from

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PIER MARIA FORNASARI
2022-07-27

How to turn muscle into a protein factory for advanced gene therapy

Interdisciplinary team of researchers from UMass Amherst and UMass Chan Medical School maps the cellular production of protein and discovers how to boost its output In a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass

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PIER MARIA FORNASARI
2022-06-12

Efficacy and safety of CD19-specific CAR T cell–based therapy in B-cell acute lymphoblastic leukemia patients with CNSL

CNS relapse is still a common cause of treatment failure in R/R B-ALL, although chemotherapy, cranial irradiation, and allo-HSCT are all modalities that can be incorporated into the management of CNSL. In the present study, published on Blood by a team of Xuzhou Medical University, was reported the efficacy, toxicity, and clinical feasibility of CD19-specific

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PIER MARIA FORNASARI
2022-06-12

First successful treatment of severe pulmonary hypertension using umbilical cord stem cells

Hannover Medical School doctors successfully treat three-year-old girl / Publication in “Nature Cardiovascular Research“ Clinical researchers at Hannover Medical School (MHH) have succeeded for the first time worldwide in stopping the usually fatal course of the disease in severe pulmonary hypertension thanks to a novel therapeutic approach. A three-year-old girl suffering from so-called pulmonary arterial

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PIER MARIA FORNASARI
2022-05-31

Recent progress in cell therapy research: a review in Nature outlines engineering disciplines, genome and epigenome editing, synthetic biology and biomaterial-mediated immune modulation.

Given recent progress in cell therapy research, it is clear that the engineering disciplines outlined in this Review will play an increasing role in the creation of new product pipelines with improved safety, efficacy and accessibility for patients. Recent scientific advances have not only demonstrated the potential impact of technologiesdeveloped by each of these fields,

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PIER MARIA FORNASARI
2022-05-30

‘Remote-controlled’ CAR-T cell therapy safer, more potent in Stanford mouse studies

Stanford researchers modified anti-cancer CAR-T cells so they can be controlled with an oral drug. The modified cells are safer, more potent and more active against solid tumors in mice. A cancer treatment that uses a patient’s own genetically modified immune cells to attack cancer cells is safer and more effective when it can be

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PIER MARIA FORNASARI
2022-05-21

‘Cell pores’ discovery and a new drug give hope to millions of brain and spinal cord injury patients

Scientists from the University of Birmingham have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord. Their research, published today in Clinical and Translational Medicine, demonstrates that AZD1236, a drug developed by AstraZeneca, can significantly reduce “secondary damage” caused by the body’s response to spinal

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Higher doses of CAR T cell therapy associate with improved outcomes in young patients with B-ALL : a report from the pediatric real-world CAR consortium

St. Jude Researchers improved CAR T-cell therapy for T-cell acute lymphoblastic leukemia

Gene Therapy Approach Shows Promise in Treating ALS

Progress toward a stem cell–based therapy for blindness

How to turn muscle into a protein factory for advanced gene therapy

Efficacy and safety of CD19-specific CAR T cell–based therapy in B-cell acute lymphoblastic leukemia patients with CNSL

First successful treatment of severe pulmonary hypertension using umbilical cord stem cells

Recent progress in cell therapy research: a review in Nature outlines engineering disciplines, genome and epigenome editing, synthetic biology and biomaterial-mediated immune modulation.

‘Remote-controlled’ CAR-T cell therapy safer, more potent in Stanford mouse studies

‘Cell pores’ discovery and a new drug give hope to millions of brain and spinal cord injury patients