Bone defects caused by various aetiologies, such as trauma, tumours, infection and congenital deformities, together with articular cartilage defects and osteochondral complex defects caused by trauma and degenerative diseases, are common clinical diseases that significantly affect the patient’s quality of life. Repair and regenerating these defects in bone and cartilage is a considerable challenge for

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Wake Forest Institute for Regenerative Medicine (WFIRM) researchers have shown the feasibility of bioengineering vascularized functional renal tissues for kidney regeneration, developing a partial augmentation strategy that may be a more feasible and practical approach than creating whole organs. In the proof-of-concept study published online this month in Acta Biomaterialia journal, the scientists created a novel

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York University scientists have uncovered a unique set of genes that play a role in muscle cellular gene expression and differentiation that could lead to new therapeutic targets to prevent the spread of muscle cancer. The researchers analyzed gene networks in muscle cells and found that the Smad7 and β-catenin proteins work co-operatively inside the

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Stem-cell based therapies to strengthen the heart muscle and treat other diseases are beginning to show promise in human clinical trials. However, other than observing clinical outcomes, lack of a repeatable, time-sensitive and noninvasive tool to assess the effectiveness of the transplanted cells within the target organ has slowed progress in the stem cell field.

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Johns Hopkins researchers have developed a way to map retinal cell development and potentially advance regenerative medicine Johns Hopkins Medicine researchers report they have created a method of mapping how the central nervous system develops by tracking the genes expressed in cells. The technique, demonstrated in mouse retinas for this study, follows the activity of

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Source Future Medicine Mesenchymal stem cells (MSCs) are in development for many clinical indications, based both on ‘stem’ properties (tissue repair or regeneration) and on signaling repertoire (immunomodulatory and antiinflammatory effects). Potential conflation of MSC properties with those of tissue-derived stromal cells presents difficulties in comparing study outcomes and represents a source of confusion in

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