Researchers at King’s College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. In a paper published today in Nature Communications, the scientists have identified a new type of cell called a hepatobiliary hybrid progenitor (HHyP), that
Scientists have invented a synthetic protein designed to control the inner workings of cells. In a pair of papers, published yesterday (July 24) in Nature, the researchers demonstrate how the tool can be used to tweak gene expression, orchestrate protein binding events, and cue functional changes in the cell in response to environmental conditions. “Cells receive stimuli, then have
Cell therapies, in which cellular material is injected, grafted, or implanted into a patient to treat a range of illnesses and medical conditions, are a vital and integral component of medicine today — promising treatment of tissue degenerative diseases, cancer, and autoimmune disorders. However, significant challenges currently exist to prevent its widespread adoption, including problems
Patients are about to be enrolled in the first study to test a gene-editing technique known as CRISPR inside the body to try to cure an inherited form of blindness. People with the disease have normal eyes but lack a gene that converts light into signals to the brain that enable sight. The experimental treatment aims to
The EU ombudsman this week said that it believes that the European Medicines Agency (EMA) should not allow the same experts to provide scientific advice to medicine developers prior to an application and evaluate the same medicine, claiming such overlap runs the risk of damaging impartiality or creating the perception of bias. In response to
Research at St. Jude Children’s Research Hospital and Massachusetts General Hospital digs into the cells of origin for key medulloblastoma subtypes Investigators at St. Jude Children’s Research Hospital and Massachusetts General Hospital, alongside others, have revealed the cells of origin for specific subtypes of medulloblastoma, the most common malignant pediatric brain tumor. The work also has implications for how
Under the umbrella of the German Biobank Node (GBN), 11 biobanks and two IT development centers are funded by the Federal Ministry of Education and Research (BMBF) to work together in the German Biobank Alliance (GBA). Their common aim is to make existing biomaterials hosted by different biobanks nationally and internationally available for biomedical research.
Source Human Gene Therapy Clinical Development Background: Cell and gene therapy products belong to a diverse class of biopharmaceuticals known as advanced therapy medicinal products. Cell and gene therapy products are used for the treatment and prevention of diseases that until recently were only managed chronically. The objective of this study was to examine the characteristics
Researchers at the University of Calgary have discovered a previously unidentified cell population with the power to heal injured hearts. The cells were found in the pericardial fluid inside the sac around the heart. Gata6+ pericardial cavity macrophage The study was led by Drs. Paul Kubes, PhD, Justin Deniset, PhD and Paul Fedak, MD, PhD. The specific
Source ARM Atara Biotherapeutics Announces Pricing of $150M Public OfferingJuly 18, 2019 – (Atara Biotherapeutics) – The offering is expected to close on or about July 23, 2019, subject to customary closing conditions. MilliporeSigma and Broad Institute Announce CRISPR License Framework to Encourage InnovationJuly 18, 2019 – (MilliporeSigma) – MilliporeSigma and the Broad Institute of MIT and Harvard
