In modern medicine, bone and dental loss and defects are common and widespread morbidities, for which regenerative therapy has shown great promise. Mesenchymal stem cells, obtained from various sources and playing an essential role in organ development and postnatal repair, have exhibited enormous potential for regenerating bone and dental tissue. Currently, mesenchymal stem cells (MSCs)-based
Mutations in Mitochondrial DNA Induced by Cell Reprogramming May Trigger Immune Response In 2006, scientists discovered a way to “reprogram” mature cells — adult skin cells, for example — into stem cells that could, in principle, give rise to any tissue or organ in the body. Many assumed it was only a matter of time
It is evident that remote field systems have the potential to greatly advance in vitro tissue engineering. However, the convergence of magnetic, optical, and acoustic technologies with in vitro tissue engineering is a relatively new development and, as a result, many studies exist only in the academic sphere and are far from disrupting the clinical
When the mice brain cells glowed, the researchers knew they were onto something. The study, from a team at Emory University School of Medicine, Atlanta Veterans Affairs Medical Center and Tzu Chi University, announces a novel, non-invasive, regenerative method called optochemogenetics that could improve stroke recovery (J. Neuroscience10.1523/JNEUROSCI.2010-18.2019). The second leading cause of death worldwide, according to the World
Source https://www.liebertpub.com/doi/pdf/10.1089/ten.teb.2018.0325 To this day, tissue reconstruction and replacement to address extensive tissue defects due to trauma, tumor resection, genetic and/or chronic diseases, or excessive debridement present a major clinical challenge. Traditional reconstructive techniques most commonly utilize autologous tissue. Undoubtedly, autologous composite tissue transfers or ‘‘flaps,’’ skin grafts, as well as the harvesting of bone
Source Global Data Gene therapy involves the delivery of complex treatments to patients. In recent years, there have been several promising clinical trial results within this field targeting an array of inherited neurodegenerative disorders, genetic diseases, and various cancers. Approvals based on these clinical trials have consequently encouraged interest in gene therapy from both industry
Overall, the growth in Asia’s bioprocessing capacity, particularly in China, has been impressive, albeit from a low baseline. Capacity growth over the past five years has been over 20 percent annually.1 New facility construction and expansions reflect the demand for biologics for domestic consumption, while other facilities are beginning to develop manufacturing strategies for GMP production
Treatments for baseball pitcher Max Scherzer and other pros may mislead fans about costly, controversial, unapproved stem cell shots. Source KHN Baseball superstar Max Scherzer — whose back injury has prevented him from pitching for the Washington Nationals since he last played on July 25 — is the latest in a long list of professional athletes to embrace unproven stem cell
Source The Scientist The company Cell Vault offers to hold consumers’ T cells for later use, but scientists suggest the service would benefit very few users. new cryopreservation bank offers customers the chance to stash away their T cells for use in future cancer treatments. Using a similar model to cord blood banks, the startup
Background: Acute liver failure is an inflammation-mediated hepatocyte injury. Mesenchymal stem cell (MSC) transplantation is currently considered to be an effective treatment strategy for acute liver failure. Exosomes are an important paracrine factor that can be used as a direct therapeutic agent. However, the use of bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) in the treatment
