Category REGENERATIVE MEDICINE

PIER MARIA FORNASARI
2019-08-19

Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration

Source https://www.liebertpub.com/doi/pdf/10.1089/ten.teb.2018.0325 To this day, tissue reconstruction and replacement to address extensive tissue defects due to trauma, tumor resection, genetic and/or chronic diseases, or excessive debridement present a major clinical challenge. Traditional reconstructive techniques most commonly utilize autologous tissue. Undoubtedly, autologous composite tissue transfers or ‘‘flaps,’’ skin grafts, as well as the harvesting of bone

Read More

No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2019-08-19

Clinical Trials: Gene Therapy

Source Global Data Gene therapy involves the delivery of complex treatments to patients. In recent years, there have been several promising clinical trial results within this field targeting an array of inherited neurodegenerative disorders, genetic diseases, and various cancers. Approvals based on these clinical trials have consequently encouraged interest in gene therapy from both industry

Read More

No Comments InGENE THERAPY RARE DISEASES
PIER MARIA FORNASARI
2019-08-19

Asia Bioprocessing Capacity Trends: Overall Growth, But Cell Therapy Shortages Loom

Overall, the growth in Asia’s bioprocessing capacity, particularly in China, has been impressive, albeit from a low baseline. Capacity growth over the past five years has been over 20 percent annually.1 New facility construction and expansions reflect the demand for biologics for domestic consumption, while other facilities are beginning to develop manufacturing strategies for GMP production

Read More

No Comments InCELL THERAPY
PIER MARIA FORNASARI
2019-08-19

Superstar Athletes Popularize Unproven Stem Cell Procedures

Treatments for baseball pitcher Max Scherzer and other pros may mislead fans about costly, controversial, unapproved stem cell shots. Source KHN Baseball superstar Max Scherzer — whose back injury has prevented him from pitching for the Washington Nationals since he last played  on July 25 — is the latest in a long list of professional athletes to embrace unproven stem cell

Read More

No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2019-08-19

Bone marrow mesenchymal stem cell-derived exosomes attenuate D-GaIN/LPS-induced hepatocyte apoptosis by activating autophagy in vitro

Background: Acute liver failure is an inflammation-mediated hepatocyte injury. Mesenchymal stem cell (MSC) transplantation is currently considered to be an effective treatment strategy for acute liver failure. Exosomes are an important paracrine factor that can be used as a direct therapeutic agent. However, the use of bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) in the treatment

Read More

No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2019-08-18

This Drug Will Save Children’s Lives. It Costs $2 Million. NYT Editorial board position

Safety, innovation and affordability need not be mutually exclusive goals for cutting-edge treatments. Source NYT Spinal muscular atrophy is a condition often fatal by age 2. Babies with the disorder have a rare genetic mutation that prevents the nervous system from controlling certain muscles. As they grow to be toddlers, these children struggle to move their limbs,

Read More

No Comments InGENE THERAPY RARE DISEASES