Category REGENERATIVE MEDICINE

PIER MARIA FORNASARI
2019-08-31

Using Electroporation and continuous-flow electrotransfection to Streamline Manufacturing of Next-Generation Cellular Therapies

A promising new treatment for cancer patients has received approval from the Centers for Medicare and Medicaid Services, paving the way for more patients to get the treatment known as CAR T-cell therapy. While this decision will likely expand access, particularly for some lymphoma and leukemia patients, treatment remains prohibitively expensive, prompting some patients to opt for experimental rather

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PIER MARIA FORNASARI
2019-08-30

Osaka University team conducts world’s first iPS transplant for corneal disease

A research team from Osaka University said Thursday it had conducted the world’s first transplant of corneal tissues using artificially derived stem cells in July. The university’s team, led by Koji Nishida, may have created a new treatment for those suffering from corneal disease, as current treatment procedures involve waiting for corneal donations from deceased

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PIER MARIA FORNASARI
2019-08-30

Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells (MA09-hRPE) in macular degeneration

The use of human embryonic stem cell (hESC)-derived Retinal Pigment Epithelium (RPE) transplants has advanced dramatically in different forms for clinical application in macular degeneration. This review focuses on the first generation of hESC-RPE cell line, named as “MA09-hRPE” by Astellas Institute of Regenerative Medicine (AIRM), and its therapeutic application in human, which evaluated the

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No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2019-08-30

Pros and cons of using organoids within R&D

Dr Shona Lang investigates the advantages and disadvantages of using organoids within R&D, highlighting the most important questions to ask before using these models. Source Drug Target Review Organoids are three-dimensional (3D) cell cultures which mimic tissue architecture. Their growing importance in various fields of research saw them named ‘Method of the Year 2017’1 and their

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PIER MARIA FORNASARI
2019-08-29

Cerebral organoids produce complex brain waves similar to newborns’

Source STAT The Lilliputian versions of human brains that scientists have grown in lab dishes have developed distinct structures such as the hippocampus, grown glia and other cells like those in actual brains, and produced a diverse menagerie of neurons that connect with each other and carry electrical signals. Now scientists have grown hundreds of cerebral organoids

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PIER MARIA FORNASARI
2019-08-29

Toward a unified theory of aging and regeneration

Source https://www.futuremedicine.com/doi/full/10.2217/rme-2019-0062 Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic

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PIER MARIA FORNASARI
2019-08-29

Addition of growth factors to unique system helps new bone formation

The development of new bone can be a multistep process: first, stem cells differentiate into cartilage cells. Next, the cartilage cells become bone cells. But that’s not all: the cells must experience some mechanical stresses during the transformation in order to transform efficiently from stem cells to bone cells. Researchers at the University of Illinois

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No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2019-08-28

Thirty patient deaths tied to cystic fibrosis drug following FDA database of side effects

Thirty patients have died after taking Symdeko, a Vertex Pharmaceuticals treatment for cystic fibrosis, according to a government database. The deaths, reported to the Food and Drug Administration’s database of side effects, are tied to Symdeko, a Vertex medicine approved last year. Reports to the database are commonly submitted by health care professionals and often contain

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No Comments InCYSTIC FIBROSIS
PIER MARIA FORNASARI
2019-08-28

The International Space Station Has a New Partner in Regenerative Medicine

Scientific investigations conducted by people on the International Space Station (ISS) are currently contributing to our knowledge in many fields. The research alliance between the University of Pittsburgh’s (Pitt) McGowan Institute for Regenerative Medicine (MIRM) and the ISS is a great example of the ultimate vision of a space development that could result in the advancement of biomedical products in space,

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