Category REGENERATIVE MEDICINE

PIER MARIA FORNASARI
2020-02-07

Advanced Therapies Apprenticeship Community roadshow showcases value of apprenticeships for upskilling in the advanced therapies industry

Workshops took place across the country to focus on the pivotal role of advanced therapies apprenticeships in addressing the skills demand in the industry. Apprentices, employers, schools and careers professionals were in attendance to consider the impact of the ATAC initiative so far and how to enhance its reach moving forward. During national apprenticeship week, the

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No Comments InCELL THERAPY
PIER MARIA FORNASARI
2020-02-06

Activating Immune Cells Could Revitalize the Aging Brain, Study on mice Suggests

Researchers at Albany Medical College in New York have discovered that a specific type of immune cell accumulates in older brains, and that activating these cells improves the memory of aged mice. The study, which has been published February 5 in the Journal of Experimental Medicine (JEM), suggests that targeting these cells might reduce age-related cognitive decline

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PIER MARIA FORNASARI
2020-02-06

Kidney stem cells can be isolated from urine

Researchers from the Institute for Stem Cell Research and Regenerative Medicine (ISRM) at the medical faculty of Heinrich Heine University-Duesseldorf under the directorship of Prof. Dr. James Adjaye have developed a protocol for the reproducible isolation and characterization of kidney stem cells, urine derived renal progenitor cells (UdRPCs) from donors of distinct ages, gender and

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No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2020-02-02

Therapeutic Mesenchymal Stromal Cells for Immunotherapy and for Gene and Drug Delivery

Mesenchymal stromal cells (MSC) possess several fairly unique properties that, combined, make them ideally suited for cellular-based immunotherapy and as vehicles for gene and drug delivery for a wide range of diseases/disorders. Key among these are: 1) their relative ease of isolation from a variety of tissues; 2) the ability to be expanded in culture

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No Comments InCELL THERAPY
PIER MARIA FORNASARI
2020-02-02

Mayo Clinic CELLTOP Clinical Trial: First Report From a Phase 1 Trial of Autologous Adipose Tissue–Derived Mesenchymal Stem Cells in the Treatment of Paralysis Due to Traumatic Spinal Cord Injury

Stem cells derived from a patient’s own fat offer a step toward improving—not just stabilizing—motor and sensory function of people with spinal cord injuries, according to early research from Mayo Clinic. A clinical trial enrolled 10 adults to treat paralysis from traumatic spinal cord injury. After stem cell injection, the first patient demonstrated improvement in motor

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PIER MARIA FORNASARI
2020-02-02

HER2-Directed CAR T-Cell Therapy Appears Active in Phase I Trial for Advanced Sarcoma

Source Targeted Oncology Patients with sarcomas, including osteosarcoma in particular, have limited treatment options available, and the landscape has not advanced in over 40 years, according to Shoba A. Navai, MD. However, trials are now evaluating the potential role of chimeric antigen receptor (CAR) T cells as treatment of patients with sarcoma. In a phase

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PIER MARIA FORNASARI
2020-01-31

UNC Lineberger discovery would allow researchers to fine-tune activity of CAR-T cancer-hunting immune cells

A discovery by University of North Carolina Lineberger Comprehensive Cancer Center researchers could allow scientists to fine-tune genetically engineered immune cells to heighten their killing power against tumors or to decrease their activity level in the case of severe side effects. In a study published in Cancer Cell, researchers led by UNC Lineberger’s Gianpietro Dotti, MD, reported

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PIER MARIA FORNASARI
2020-01-31

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

Source Cell Metabolism Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, it’s reported that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. Depletion of

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PIER MARIA FORNASARI
2020-01-30

NUS Medicine researchers can now reprogramme cells to revert to original state for regenerative medicine

Inducing totipotency into stem cells outside of embryos will allow maximal cell engineering for therapeutic purposes Early mammalian development is a highly complex process involving elaborate and highly coordinated biological processes. One such process is zygotic genome activation (ZGA) which occurs following the union of the sperm and egg, marking the beginning of life. The

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PIER MARIA FORNASARI
2020-01-30

Penn Researchers Identify Cancer Cell Defect Driving Resistance to CAR T Cell Therapy

Study identifying mechanism that prevents cell death may guide future immunotherapy strategies Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research from the Abramson Cancer Center of the University of Pennsylvania is shedding light on why. In a new study, researchers describe how a

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