Why patients with hypertension, diabetes mellitus and ibuprofen usage could be at increased risk for COVID-19 infection?
A letter, recently published on Lancet, suggests that ACE inhibitors, ARBs and ibuprofen results in upregulation of ACE2 receptors. Human pathogenic coronaviruses (severe acute respiratory syndrome coronavirus [SARS-CoV] and SARSCoV-2) bind to their target cells through angiotensin-converting enzyme 2 (ACE2), which is expressed by epithelial cells of the lung, intestine, kidney, and blood vessels. The