Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. The autors aimed to provide a clinicopathological report
An autopsy-based study of 11 people who died from COVID-19 shows a mismatch between viral hotspots in the body and sites of inflammation and organ damage. This suggests that immune responses, rather than the virus itself, are responsible for death. The survey of 37 anatomical sites, including lungs, found that some tissues harboured the virus
More than 3,5 million people in the United States have been infected with COVID-19 and more than 138,000 have died. More people have died of COVID-19 in the U.S. than in any other country, but few studies offer national data on the factors that may contribute to outcomes for critically ill patients. To address this
This study, published on JAMA, evaluates the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. This retrospective, observational cohort study includes 3988 consecutive critically ill patients with laboratory-confirmed COVID-19 referred forICU admission to the coordinating center of the COVID-19 Lombardy ICU Network from
We have good reason to be cautious about these high profile options The devastating pandemic caused by the SARS-CoV-2 coronavirus appears to be a prime candidate for traditional prevention (vaccines) and passive immunity approaches. Passive immunity, using convalescent plasma from recovered patients or monoclonal antibodies with high levels of neutralising antiviral activity, have potential for
Coronavirus disease 2019 (COVID-19) is associated with a high disease burden with 10% of confirmed cases progressing towards critical illness. Nevertheless, the disease course and predictors of mortality in critically ill patients are poorly understood. Following the critical developments in ICUs in regions experiencing early inception of the pandemic, the European-based, international RIsk Stratification in
The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatalorgan failure. The authors report the fundamental pathological investigation in the lungs and other organs of fatal cases after the autopsy and pathological investigations of specimens performed on
A team of University of Pavia, Italy presents on Lancet the case of 16-year-old boy admitted to emergency department, complaining of intense chest pain started 1 h earlier. The day before he had a fever of 38·3°C thatdecreased after 100 mg of nimesulide. He reported no other symptoms, no medical history, and no contact with
Researchers of Harvard Medical School, Boston have devised a way to decontaminate N95 respirators using household supplies: glass containers, mesh from produce bags, a rubber band, and a microwave. The paper by Zulauf KE, Green AB, Nguyen Ba AN, Jagdish T, Reif D, Seeley R, Dale A, Kirby JE has been published on mBio 11:e00997-20.
University of Oxford’s RECOVERY trial published its much anticipated preprint paper on the drug’s effect on Covid-19. The paper states that the drug cuts deaths in ventilated patients by one third and deaths in other admitted patients receiving oxygen by only one fifth. The headline findings of the trial were reported by the investigators on 16
