Category Covid-19

PIER MARIA FORNASARI
2020-07-19

A synergistic role of convalescent plasma and mesenchymal stem cells in the treatment of severely ill COVID-19 patients: a clinical case report

Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and has the risk of long-term transmission. No effective treatment has been discovered to date. In the cases reported, the patient continued to deteriorate even after administration of

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PIER MARIA FORNASARI
2020-07-19

Haematological characteristics and risk factors in the classification and prognosis evaluation of COVID-19: a retrospective cohort study

COVID-19 is an ongoing global pandemic. Changes in haematological characteristics in patients with COVID-19 are emerging as important features of the disease. The authors aimed to explore the haematological characteristics and related risk factors in patients with COVID-19. This retrospective cohort study included patients with COVID-19 admitted to three designated sites of Wuhan Union Hospital

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PIER MARIA FORNASARI
2020-07-17

Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. The autors aimed to provide a clinicopathological report

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PIER MARIA FORNASARI
2020-07-16

Risk Factors Associated With Mortality Among Patients With COVID-19 in Intensive Care Units in Lombardy, Italy

This study, published on JAMA, evaluates the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in ICUs in the Lombardy region of Italy. This retrospective, observational cohort study includes 3988 consecutive critically ill patients with laboratory-confirmed COVID-19 referred forICU admission to the coordinating center of the COVID-19 Lombardy ICU Network from

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PIER MARIA FORNASARI
2020-07-15

Vaccines, convalescent plasma and monoclonal antibodies for Covid-19: Sewell editorial on BMJ

We have good reason to be cautious about these high profile options The devastating pandemic caused by the SARS-CoV-2 coronavirus appears to be a prime candidate for traditional prevention (vaccines) and passive immunity approaches. Passive immunity, using convalescent plasma from recovered patients or monoclonal antibodies with high levels of neutralising antiviral activity, have potential for

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PIER MARIA FORNASARI
2020-07-15

Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Coronavirus disease 2019 (COVID-19) is associated with a high disease burden with 10% of confirmed cases progressing towards critical illness. Nevertheless, the disease course and predictors of mortality in critically ill patients are poorly understood. Following the critical developments in ICUs in regions experiencing early inception of the pandemic, the European-based, international RIsk Stratification in

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PIER MARIA FORNASARI
2020-06-28

Alveolar macrophage dysfunction in the pathogenesis of two severe COVID-19 patients

The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatalorgan failure. The authors report the fundamental pathological investigation in the lungs and other organs of fatal cases after the autopsy and pathological investigations of specimens performed on

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