Category Covid-19

PIER MARIA FORNASARI
2020-09-23

NIH, receiving $48 million in support through Operation Warp Speed (OWS), expands clinical trials to test convalescent plasma against COVID-19

Rigorous studies to build on earlier efforts to test the experimental treatment Source NIH Two randomized, placebo-controlled clinical trials funded by the National Institutes of Health (NIH) are expanding enrollment to further evaluate convalescent plasma as a treatment for patients hospitalized with COVID-19. Preliminary observational studies indicate that convalescent plasma may improve outcomes among severely

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PIER MARIA FORNASARI
2020-09-23

People with asymptomatic SARS-CoV-2 infection have an upper respiratory viral load as those with mild symptoms

They are relatively common so may act as important driver of viral spread, warn researchers People with ‘silent’ COVID-19 infection have as much coronavirus in their noses and throats as those with symptoms, reveals research published online in the journal Thorax. Given how many of these people there are—a fifth of those infected, the study findings show–they may

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PIER MARIA FORNASARI
2020-09-21

Endothelial damage and a thin intercellular fibrin network promote coagulation disorders in acute promyelocytic leukaemia: a model for severe Covid-19 thrombo-hemorrhagic complications.

So far, early hemorrhagic death remains a major obstacle to complete remission in acute promyelocytic leukemia (APL). The number of leukemia cells in the blood is a better predictor of bleeding events than other hematological parameters. Vascular endothelial homeostasis is associated with spontaneous bleeding. In APL, how APL cells interact with vascular endothelial cells and

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PIER MARIA FORNASARI
2020-09-17

FDA Approves Study to Investigate the Use of Cell Therapy to Treat COVID-19 Related Multisystem Inflammatory Syndrome in Children (MIS-C)

First-of-its kind study to be supported by the Cura Foundation, The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now The Cura Foundation in collaboration with The Marcus Foundation, Sanford Health and Alliance for Cell Therapy Now, is supporting a clinical trial of human cord tissue mesenchymal stromal cells (hCT-MSC) to treat children with

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PIER MARIA FORNASARI
2020-09-16

Frequency of Children vs Adults Carrying Severe Acute Respiratory Syndrome Coronavirus 2 Asymptomatically

The frequency of children carrying asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been suggested to be higher than among adults. It is also suggested that asymptomatic children enhance viral spread. A research letter by published in the journal JAMA Pediatrics in September 2020 explores the truth of this common belief. Earlier Research Earlier studies

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PIER MARIA FORNASARI
2020-09-16

Efficacy of convalescent plasma against COVID19 requires early therapy with high titer plasma. RCTs need to be designed on this basis.

In a paper published on EClinicalMedicine, has been assessed outcome of patients with moderate and severe COVID-19 following treatment with convalescent plasma (CP) and the association with IgG levels in transfused CP. A prospective cohort study. Primary outcome was improvement at day 14 defined as alive, not on mechanical ventilation, and moderate, mild, or recovered

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PIER MARIA FORNASARI
2020-09-15

Assessment of the immune response in kids with MIS-C, identifying candidate autoantibodies resembling antibody response to convalescent Covid.

Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. In thi paper on Cell, are reported the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2

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