Category Covid-19

PIER MARIA FORNASARI
2021-03-14

Neutrophil activation tracks most closely with severe COVID-19 progression: a study on temporal and resolution dynamics of the host molecular responses confirms the main role of neutrophil proteolytic storm

The coronavirus disease-19 (COVID-19) pandemic has cost lives and economic hardships globally. Various studies have found a number of different factors, such as hyperinflammation and exhausted/suppressed T cell responses to the etiological SARS coronavirus-2 (SARS-CoV-2), being associated with severe COVID-19. However, sieving the causative from associative factors of respiratory dysfunction has remained rudimentary. In this

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PIER MARIA FORNASARI
2021-03-13

Vaccine-induced antibodies may be less effective against several new SARS-CoV-2 variants

Key Takeaways Neutralizing antibodies induced by the Pfizer and Moderna COVID-19 vaccines were significantly less effective against the variants first described in Brazil/Japan and South Africa. While the ability of these variants to resist neutralizing antibodies is concerning, it doesn’t mean the vaccines won’t be effective. Understanding which mutations are most likely to allow the

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PIER MARIA FORNASARI
2021-03-12

Obesity linked to higher risk for poor COVID-19 outcomes

The risk for invasive mechanical ventilation, hospitalization and death in those with COVID-19 increased with BMI, according to research published in MMWR. “The findings in this report highlight a dose-response relationship between higher BMI and severe COVID-19–associated illness and underscore the need for progressively intensive illness management as obesity severity increases,” LyudmylaKompaniyets, PhD, a postdoctoral research fellow at the CDC,

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PIER MARIA FORNASARI
2021-03-12

Protease inhibitors drugs Camostat and Nafamostat inhibit new SARS-CoV-2 activators identified in the upper respiratory tract, blocking virus cell entry.

There are no therapeutics available that have been developed for COVID-19 treatment. Repurposing of already available medication for COVID-19 therapy is an attractive option to shorten the road to treatment development. The drug Camostat could be suitable. Camostat exerts antiviral activity by blocking the protease TMPRSS2, which is used by SARS-CoV-2 for entry into cells.

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PIER MARIA FORNASARI
2021-03-12

UK Royal College of Physicians calls for urgent measures to protect and safeguard medical workforce involved in fight against Covid-19

In an article published in The Lancet, RCP president Professor Andrew Goddard and RCP Global vice president Dr Mumtaz Patel call for system-wide support to protect clinicians from harm. The COVID-19 pandemic has placed huge demands on global health systems which are testing doctors and health-care workers to the limits of their professional competence and taking

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PIER MARIA FORNASARI
2021-03-12

A new study on BMJ shows an increase in deaths from 2.5 to 4.1 per 1000 detected cases in SARS-CoV-2 B.1.1.7 variant

A highly infectious variant of COVID-19 that has spread around the world since it was first discovered in Britain late last year is between 30% and 100% more deadly than previous dominant variants, researchers said on Wednesday. In a study that compared death rates among people in Britain infected with the new SARS-CoV-2 variant known

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PIER MARIA FORNASARI
2021-03-06

NIH/NIDDK Researchers propose that masking induced humidity, hydrating the respiratory tract, may lessen severity of COVID-19

Masks help protect the people wearing them from getting or spreading SARS-CoV-2, the virus that causes COVID-19, but now researchers have added evidence for yet another potential benefit for wearers: The humidity created inside the mask may help combat respiratory diseases such as COVID-19. Masks help protect the people wearing them from getting or spreading

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