Category Covid-19

PIER MARIA FORNASARI
2021-12-28

Complement activation induces excessive T cell cytotoxicity in severe COVID-19, associated with fatal outcome.

A new paper published in Cell by Charitè group opens new perspectives to complement role in Covid-19 Highlights •Severe COVID-19 is marked by activated, highly cytotoxic CD16+ T cells •Immune complex-mediated degranulation of CD16+ T cells causes endothelial cell injury •C3a-rich environment in severe COVID-19 promotes differentiation of CD16+ T cells •Activated CD16+ T cells and complement proteins are

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PIER MARIA FORNASARI
2021-12-27

Analysis of COVID-19 Vaccine Type and Adverse Effects Following Covid-19 Vaccination

This article was originally published here JAMA Netw Open. 2021 Dec 1;4(12):e2140364. doi: 10.1001/jamanetworkopen.2021.40364. ABSTRACT IMPORTANCE: Little is known about the factors associated with COVID-19 vaccine adverse effects in a real-world population. OBJECTIVE: To evaluate factors potentially associated with participant-reported adverse effects after COVID-19 vaccination. DESIGN, SETTING, AND PARTICIPANTS: The COVID-19 Citizen Science Study, an online

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PIER MARIA FORNASARI
2021-12-27

When and how to use the existing tests to detect SARS-CoV-2 virus

“Test, test, test.” This is how Tedros Adhanom , director general of the World Health Organization (WHO), urged the countries  at the beginning of the covid-19 pandemic. Testing, isolation and contact tracing should be – and have been in many cases – the “backbone of the global response” to the crisis, according to the head of the agency. According to experts,

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PIER MARIA FORNASARI
2021-12-27

The Omicron variant is highly resistant against antibody-mediated neutralization: a new study on Cell shows

The rapid spread of the SARS-CoV-2 Omicron variant suggests that the virus might become globally dominant. Further, the high number of mutations in the viral spike-protein raised concerns that the virus might evade antibodies induced by infection or vaccination. In thi paper on Cell are reported that the Omicron spike was resistant against most therapeutic

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PIER MARIA FORNASARI
2021-12-17

Discovery Health, South Africa’s largest private health insurance administrator, releases at-scale, real-world analysis of Omicron outbreak based on 211 000 COVID-19 test results in South Africa.

Summary: Vaccine effectiveness: o The two-dose Pfizer-BioNTech vaccination provides 70% protection against severe complications of COVID-19 requiring hospitalisation, and 33% protection against COVID-19 infection, during the current Omicron wave. Reinfection risk: For individuals who have had COVID-19 previously, the risk of reinfection with Omicron is significantly higher, relative to prior variants. Severity: The risk of hospital admission

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PIER MARIA FORNASARI
2021-12-16

HKUMed researchers find Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung

A study led by researchers from the LKS Faculty of Medicine at The University of Hong Kong (HKUMed) provides the first information on how the novel Variant of Concern (VOC) of SARS-CoV-2, the Omicron SARS-CoV-2 infect human respiratory tract. The researchers found that Omicron SARS-CoV-2 infects and multiplies 70 times faster than the Delta variant

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PIER MARIA FORNASARI
2021-12-16

Universal Coronavirus Vaccines: an Urgent Need. Global coronaviral approach requested by Fauci and NIH researchers

A growing body of scientific evidence, considered together with ecological reality, strongly suggest that novel coronaviruses will continue to infect bats and other animal reservoirs and potentially emerge to pose a pandemic threat to humans. To counter future coronavirus outbreaks, the global scientific and medical research community should focus a major effort now on three

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PIER MARIA FORNASARI
2021-12-16

Fostering experimental and computational synergy to modulate hyperinflammation in severe Covid-19

An international collaboration between researchers from the Center for Cooperative Research in Biosciences (CIC bioGUNE, Bilbao), the Luxembourg Centre for Systems Biomedicine (LCSB) at the University of Luxembourgand and the Department of Immunology of St Jude Children’s Research Hospital (Kanneganti Lab, Memphis) highlights how fostering synergies between computational and experimental studies can lead to important

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PIER MARIA FORNASARI
2021-12-15

Risks of myocarditis, pericarditis, and cardiac arrhythmias are more likely associated with Covid-19 infection than with vaccination

Led by the University of Oxford, a team of UK-based researchers have today reported results of the largest ever study to compare the risks of cardiovascular events, such as myocarditis, pericarditis, and cardiac arrhythmia, between different vaccines and COVID-19 infection, and the first to investigate the association between cardiac events and the Oxford-AstraZeneca vaccine. While

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