To become, or not to become… a neuron. Scientists find a factor that makes neural stem cells “deaf” to proliferative signals, turning them into neurons

Researchers led by Pierre Vanderhaeghen and Jérôme Bonnefont (VIB-KU Leuven and ULB), in collaboration with Stein Aerts (VIB KU Leuven) and François Guillemot (Crick Institute), have unraveled a new mechanism controlling the switch between growth and differentiation of neural stem cells during brain development. They discovered a specific factor that makes stem cells ‘deaf’ to proliferative signals,

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Some health websites are notoriously misleading: their reliability rated

Source STAT For millions of Americans, including health professionals, the resurgence of measles is a confounding and frightening development. How can a disease declared eliminated nearly two decades ago come back when it can be prevented with a vaccine proven to be safe and effective? But that’s not the reality for those getting their health information from

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Liver transplants could be redundant with discovery of new liver cell

Researchers at King’s College London have used single cell RNA sequencing to identify a type of cell that may be able to regenerate liver tissue, treating liver failure without the need for transplants. In a paper published today in Nature Communications, the scientists have identified a new type of cell called a hepatobiliary hybrid progenitor (HHyP), that

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Designer Protein Acts as a Switch for Cellular Circuitry

Scientists have invented a synthetic protein designed to control the inner workings of cells. In a pair of papers, published yesterday (July 24) in Nature, the researchers demonstrate how the tool can be used to tweak gene expression, orchestrate protein binding events, and cue functional changes in the cell in response to environmental conditions.  “Cells receive stimuli, then have

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MIT’s research enterprise in Singapore launches new group, boosting cell therapy research

Cell therapies, in which cellular material is injected, grafted, or implanted into a patient to treat a range of illnesses and medical conditions, are a vital and integral component of medicine today — promising treatment of tissue degenerative diseases, cancer, and autoimmune disorders.  However, significant challenges currently exist to prevent its widespread adoption, including problems

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Regulating Digital Health: Novartis CEO Seeks Further Modernization

Novartis CEO Vas Narasimhan told attendees of PhRMA’s Innovation Day on Thursday that as biopharmaceutical companies embrace digital technologies to speed the discovery and development of new medicines, regulators will have to adapt more quickly. “FDA has been, more than any other regulator in the world, interested in working with these technologies,” Narasimhan said. But

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