Injuries to nerve fibers in the brain, spinal cord, and optic nerves usually result in functional losses as the nerve fibers are unable to regenerate. A team from the Department of Cell Physiology at Ruhr-Universität Bochum (RUB) led by Professor Dietmar Fischer has deciphered new mechanisms that enable the regeneration of such fibers. This could
Removal of the genetic defect that causes Friedreich’s ataxia (FA) in heart cells derived from a patient with heart disease associated with FA reversed the cells’ abnormal molecular profile, a study shows. This gene-editing strategy could be a useful tool for regenerative medicine aimed at treating heart defects associated with the condition. The study, “Excision of the
The CRISPR Journal announces the publication of its August 2019 issue. The Journal is dedicated to validating and publishing outstanding research and commentary on all aspects of CRISPR and gene editing, including CRISPR biology, technology, and genome editing, and commentary and debate of key policy, regulatory, and ethical issues affecting the field. The Journal, led by
A new international study co-led by Cleveland Clinic has identified a new drug target for treating glioblastoma. This target is part of a never-before defined cellular pathway found to contribute to the spread and proliferation of a dangerous subset of cancer cells, called glioma stem cells. While previous research has shown that a protein called
A new scalable, high-throughput fabrication process that makes use of roll-to-roll printing and laser cutting can produce wearable sweat sensors rapidly and reliably and on a large scale. The devices, which can almost instantly detect and analyse electrolytes, metabolites and other biomolecules contained in sweat, could be employed in real-world applications and not just as laboratory
South Korea is seeking to ease legislative restrictions to allow research on breakthrough gene therapies using gene editing and other advanced gene correction tools. The Ministry of Health and Welfare said on Thursday it is revising the Bioethics Act to allow gene therapy research in this direction. Rep. Yoon Il-kyu of the ruling Democratic Party,
There’s hope a gene therapy being developed at the Australian National University could one day help save the eyesight of millions. The therapy is working on preventing the loss of eyesight from dry age-related macular degeneration (dry AMD). Dry AMD is a common disorder that is caused by damage to the macula – the part
As more cell therapy products reach the “finish line” of U.S. Food and Drug Administration (FDA) approval and new regenerative medicine products begin the clinical development process, the need for expanded manufacturing capacity that can support long-term commercial business models is increasing. Recently, David Smith, Alex Klarer, Thomas Heathman, Courtney LeBlon, Yasuhiko Tada and Brian
Agency’s jurisdiction over regenerative therapies upheld in landmark court ruling The Food and Drug Administration and members of Congress have taken important steps in recent months to protect consumers from unproven and risky stem cell products offered by hundreds of clinics nationwide. However, the agency needs to take broader action to deter businesses from selling
Engineers program human and bacterial cells to keep a record of complex molecular events Using a technique that can precisely edit DNA bases, MIT researchers have created a way to store complex “memories” in the DNA of living cells, including human cells. The new system, known as DOMINO, can be used to record the intensity,
