Interest in machine-learning applications within medicine has been growing, but few studies have progressed to deployment in patient care. We present a framework, context and ultimately guidelines for accelerating the translation of machine-learning-based interventions in health care. To be successful, translation will require a team of engaged stakeholders and a systematic process from beginning (problem
The FDA approved upadacitinib (Rinvoq, AbbVie), a 15-mg, once-daily oral Janus kinase inhibitor, for the treatment of adults with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to methotrexate. The approval is supported by data from the SELECT program, one of the largest registrational phase 3 clinical programs
For transplant patients, the body’s own defences can be fatal. Breakthrough research offers new hope Source Robert Lechler on Financial Times “Although I was well aware of the time ticking away throughout the procedure — everyone was — I could only continue to work carefully and systematically and, at all costs, efficiently,” surgeon Joseph Murray
California Institute for Regenerative Medicine awarded a $9.28 million grant will support a clinical trial at City of Hope to evaluate chimeric antigen receptor T-cell therapy for patients with HER2-positive breast cancer that spread to the brain. About 20% of breast cancers are HER2-positive, and nearly half of women with this type of breast cancer develop brain
A team of researchers including those from Biotechnology Center of the TU Dresden (BIOTEC), have found that stem cells could be used for several forms of tissue engineering including tooth repair. Study leader Dr Bing Hu of the Peninsula Dental School of the University of Plymouth, published the results of the study titled, “Transit amplifying
AI and machine learning can transform data from health records — “real world data” — into “real world evidence” that will bolster the medical community’s collective knowledge exponentially. Yet, clinical decision support platforms are the only way all this added practice-based knowledge can actually be used to improve overall care. Since Stanford Medicine’s 2018 Health Trends
The study reveals how cells can be pushed into producing more internal energy leading to better cell factories. Researchers have uncovered some of the secrets of how cells generate and use energy. A new study has revealed it is possible to evoke a shift in the metabolism from fermentation to respiration of E. coli and baker’s yeast by toying
It could lead to a new generation of personalized artificial organs. Bioprinting holds great potential for repairing injuries, testing drugs or replacing whole organs, but it’s currently limited in complexity, viability and speed — you can’t just create tissue on a whim. Soon, though, it might be a matter of crafting whatever you need when you need
Rexgenero, a regenerative medicine company pioneering the development of advanced cell-based therapies to treat chronic limb-threatening ischaemia (CLI), welcomes the news announced today by Atelerix that it has been awarded a grant of £267,000 from Innovate UK. The grant will be used to develop gel stabilisation technologies, developed by Atelerix, with the first objective of extending the
Research shows nearly every sixth death in the world is due to the disease, making it the second leading cause of death behind cardiovascular diseases. The global pharmaceutical industry is estimated at an astounding $1.11 trillion in size. Every year, billions are spent on the research and development of cancer drugs, with numerous trials conducted in an
