Statement by the World Health Organization in support of cOAlition S Today, WHO announces it is the first of the United Nations agencies to join a coalition of research funders and charitable foundations (cOAlition S), an initiative to make full and immediate open access to research publications a reality. cOAlition S is built around Plan S,
The use of human embryonic stem cell (hESC)-derived Retinal Pigment Epithelium (RPE) transplants has advanced dramatically in different forms for clinical application in macular degeneration. This review focuses on the first generation of hESC-RPE cell line, named as “MA09-hRPE” by Astellas Institute of Regenerative Medicine (AIRM), and its therapeutic application in human, which evaluated the
Sonic Hedgehog Medulloblastoma Can Turn into a Stubborn Killer of Children One of the most common brain cancers in children, Sonic Hedgehog (SHH) medulloblastoma, also is one of the more survivable for most kids. Unfortunately, for a subset of patients the cancer resists treatment and relapses with a vengeance to then turn deadly. Researchers at Cincinnati
Dr Shona Lang investigates the advantages and disadvantages of using organoids within R&D, highlighting the most important questions to ask before using these models. Source Drug Target Review Organoids are three-dimensional (3D) cell cultures which mimic tissue architecture. Their growing importance in various fields of research saw them named ‘Method of the Year 2017’1 and their
The U.S. Food and Drug Administration today approved the first spinal tether device intended to be used in children and adolescents to correct the most common form of scoliosis, called idiopathic scoliosis, that has not responded to conservative treatment options, such as external bracing. The device, called The Tether – Vertebral Body Tethering System, is
Source STAT The Lilliputian versions of human brains that scientists have grown in lab dishes have developed distinct structures such as the hippocampus, grown glia and other cells like those in actual brains, and produced a diverse menagerie of neurons that connect with each other and carry electrical signals. Now scientists have grown hundreds of cerebral organoids
The Personalized Medicine Coalition (PMC) released its annual “Personalized Medicine At FDA: A Progress & Outlook Report” (Report) that monitors current successes and challenges in bringing personalized therapies to market. Notable Developments for 2018 Several milestones were noted for 2018 – ranging from new drug approvals to direct-to-consumer genetic testing. 1. A record number of
Source https://www.futuremedicine.com/doi/full/10.2217/rme-2019-0062 Growing evidence supports the antagonistic pleiotropy theory of mammalian aging. Accordingly, changes in gene expression following the pluripotency transition, and subsequent transitions such as the embryonic–fetal transition, while providing tumor suppressive and antiviral survival benefits also result in a loss of regenerative potential leading to age-related fibrosis and degenerative diseases. However, reprogramming somatic
The development of new bone can be a multistep process: first, stem cells differentiate into cartilage cells. Next, the cartilage cells become bone cells. But that’s not all: the cells must experience some mechanical stresses during the transformation in order to transform efficiently from stem cells to bone cells. Researchers at the University of Illinois
Scientists from Basel have investigated the activity of stem cells in the brain of mice and discovered a key mechanism that controls cell proliferation. According to the researchers, the gene regulator Id4 controls whether stem cells remain in a state of rest or enter cell division. The results were published in “Cell Reports” and may
