All posts by PIER MARIA FORNASARI

PIER MARIA FORNASARI
2019-09-12

Engineered triple inhibitory receptor resistance improves anti-tumor CAR-T cell performance via CD56

The inhibitory receptors PD-1, Tim-3, and Lag-3 are highly expressed on tumor-infiltrating lymphocytes and compromise their antitumor activity. For efficient cancer immunotherapy, it is important to prevent chimeric antigen receptor T (CAR-T)-cell exhaustion. Here we downregulate these three checkpoint receptors simultaneously on CAR-T cells and that show the resulting PTL-CAR-T cells undergo epigenetic modifications and better control

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No Comments InCAR-T
PIER MARIA FORNASARI
2019-09-12

Teaming Magnetic Bacteria with Nanoparticles for Better Drug Delivery

Nanoparticles hold great promise for delivering next-generation therapeutics, including those based on CRISPR gene editing tools. The challenge is how to guide these tiny particles through the bloodstream and into the right target tissues. Now, scientists are enlisting some surprising partners in this quest: magnetic bacteria! Source NIH Director First a bit of background. Discovered in

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No Comments InRESEARCH
PIER MARIA FORNASARI
2019-09-12

MRC’s first decade of translation funding led to £1.1 billion private investment and new therapies

A new report has found that Medical Research Council (MRC) funding schemes for translational research have boosted the UK’s life sciences industry since they were introduced in 2008.  Over £530 million of new translational research funding since 2008 has led to MRC-linked spin-outs securing £1.1 billion in private sector investment and delivering health benefits, such as new

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No Comments InRESEARCH
PIER MARIA FORNASARI
2019-09-12

Director of Besta Neurologic Institute of Milan:”There is no experimental stem cell-based treatment that has a positive effect for patients in a state of minimal consciousness like Michael Schumacher.”

Source Il Messaggero Matilde Leonardi, director of the Coma Research Center of the Besta Neurological Institute in Milan and a member of the Italian Society of Neurology, wants to be immediately clear. “The news about the former pilot is only fueling false hopes and deluding patients’ families.” Why is she so convinced that this therapy

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No Comments InREGENERATIVE MEDICINE
PIER MARIA FORNASARI
2019-09-12

George Washington University researcher receives grant to develop 4D technology that prints heart tissue

The School of Engineering and Applied Science announced late last month that a mechanical and aerospace engineering professor received $300,000 from the American Heart Association to develop a device that can print tissue used for repairing heart damage. The AHA – a nonprofit organization that funds cardiovascular research – granted a three-year award to Lijie

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No Comments InBIOPRINTING
PIER MARIA FORNASARI
2019-09-11

Translating Biofabrication to the Market

Biofabrication holds great potential to revolutionize important industries in the health, food, and textile sectors, but its translation to market is still challenging. Pedro F. Costa in a paper newly published on Trends in Biotechnology analyzes the current state of innovation and commercialization in biofabrication and try to assess its limitations, strengths, and future progress.

No Comments InBIOPRINTING
PIER MARIA FORNASARI
2019-09-11

New AI neural network approach detects heart failure from a single heartbeat with 100% accuracy

Researchers have developed a neural network approach that can accurately identify congestive heart failure with 100% accuracy through analysis of just one raw electrocardiogram (ECG) heartbeat, a new study reports. Nearly 10 percent of adults over the age of 65 suffer from some kind of congestive heart failure (CHF). There are a variety of different

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No Comments InARTIFICIAL INTELLIGENCE
PIER MARIA FORNASARI
2019-09-11

Osteoporosis-related fractures could cost Medicaid more than $6 billion in hospital costs

Approximately 2.3 Million Fractures Suffered by 2 Million on Medicare; Proven Preventive Measures Go Largely Unused Source NOF A new report released today by the National Osteoporosis Foundation (NOF) finds that despite the existence of proven preventive measures, approximately 2 million Americans on Medicare suffered 2.3 million osteoporosis-related bone fractures in 2015. These totals mean osteoporotic

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No Comments InWELLNESS