Women in early menopause treated with zoledronate in just two infusions, 5 years apart, show a significantly reduced risk of sustaining a vertebral fracture and better maintenance of bone mineral density (BMD) over a 10-year period than those receiving just one or no infusions over the period, suggesting the infrequent, early dosing to be a
Megakaryocytes (MKs) are traditionally recognized for their crucial role in platelet production, which is vital for hemostasis and coagulation. However, recent studies have illuminated their far-reaching involvement in immune responses within both physiological and pathological environments. Advances in immunology and cellular biology have revealed the significant immunomodulatory functions of MKs, changing our understanding from their
Every 40 seconds, someone in the United States has a stroke. For survivors of the most common type of stroke, called an ischemic stroke, only about 5 percent fully recover. Most others suffer from long-term problems, including weakness, chronic pain, or epilepsy. Now, scientists at Gladstone Institutes and the regenerative medicine company SanBio have shown
Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes Summary Osteosarcoma is a type of aggressive bone cancer that most commonly affects children and young adults between the ages of 10 and 20, during times of rapid bone growth. Although rare, it has a significant impact on young people
A team of researchers from the Translational Oncology Research Centre (TORC) of Vrije Universiteit Brussel (VUB), in collaboration with leading German universities, has developed a new biomaterial with high potential in in the treatment of bone lesions The team tackled a critical challenge in treating multiple myeloma—a blood cancer where malignant plasma cells accumulate in
Phase I clinical trial led by researchers at University of California San Diego School of Medicine has demonstrated the long-term safety and feasibility of neural stem cell transplantation for treating chronic spinal cord injuries. These devastating injuries often result in partial or full paralysis and are currently incurable. The study, which followed four patients with
Researchers at Hospital for Special Surgery (HSS) have pinpointed a cellular target that could enhance the way osteoporosis and other metabolic bone diseases are diagnosed and treated. The findings, published recently in JCI Insight, reveal that circulating osteoclast precursor cells (cOCPs) play a pivotal role in bone loss. The study is also the first of its kind
Researchers from the Vienna Lung Transplant Program of MedUni Vienna and University Hospital Vienna have published the first prospective, randomized and controlled study on the use of extracorporeal photopheresis (ECP) in lung transplantation in the renowned European Respiratory Journal. The findings could significantly change the standard procedure for rejection reactions after lung transplants. Extracorporeal photopheresis
An international research team led by the University of California, Irvine has discovered a new type of skeletal tissue that offers great potential for advancing regenerative medicine and tissue engineering. Most cartilage relies on an external extracellular matrix for strength, but “lipocartilage,” which is found in the ears, nose and throat of mammals, is uniquely
Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University’s Ithaca campus. The human body has co-evolved with the beneficial microbes that live in the gut (termed the microbiota), resulting in mutually
