An 18-year survivor of neuroblastoma, a solid childhood tumor that develops in immature nerve cells, is believed to represent the longest reported remission to date in a patient treated with chimeric antigen receptor (CAR) T cell therapy. The findings, published in Nature Medicine, describe several long-term survivors in a follow-up from a phase 1 clinical trial
GLP-1 medications initially were used to help people with diabetes improve their insulin resistance and hunger cravings. However, over the past few years, these medications have become popular due to their weight loss and weight management benefits. Outside of nutrition, physical activity and surgery, Dr. Saundra Nguyen, assistant professor of internal medicine at Baylor College of Medicine, explaining
A simple scoring system could revolutionise how doctors prevent heart attacks and strokes by identifying patients most likely to benefit from preventive medications, according to a new study. The breakthrough test, called the TRIPLE Score, (Thrombotic Reactivity Indicator using Platelet GPVI, CD36 [cluster of differentiation 36] Expression, and age) measures specific proteins on blood platelets
The American Academy of Neurology (AAN) has developed a new systematic review to summarize for neurologists and other clinicians the evidence for epidural steroid injections and whether they reduce pain and disability for people with certain kinds of chronic back pain. The systematic review is published on February 12, 2025, online in Neurology®. It updates
Blood thinners prescribed after blood clots in leg or lung initially increase the risk of bleeding, especially in women and elderly. But over time, this risk decreases and gender and age differences fade, a University of Gothenburg study shows. The aim of the study, published in the Journal of Internal Medicine, was to investigate the
Up to half of all people living with Alzheimer’s Disease in Ireland remain undiagnosed. A new blood test may have the potential to transform patient care, allowing for better diagnosis, earlier interventions and more targeted treatments Researchers at Trinity College, the Tallaght Institute of Memory and Cognition and St James’s Hospital, Dublin are exploring the
Called PAC-MANN, the test developed at OHSU could help save lives A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the deadliest cancers. Researchers at Oregon Health & Science University have developed a test called PAC-MANN, the abbreviation for “protease activity-based assay using a magnetic nanosensor,”
A 3D-printed, bioresorbable heart valve promotes tissue regeneration, potentially eliminating the need for repeated surgeries for adult and pediatric heart patients. Every year, more than 5 million people in the U.S. are diagnosed with heart valve disease, but this condition has no effective long-term treatment. When a person’s heart valve is severely damaged by a birth defect,
Researchers at McMaster University have made a groundbreaking discovery in the field of hematology, providing an explanation for spontaneous and unusual bleeding episodes that continue to occur despite treatment with full-dose blood thinners. The discovery, published February 12, 2025 in The New England Journal of Medicine is expected to impact the way doctors test and treat patients
Analysis looked for—and did not find—examples where the process of generating CAR T cells caused malignancy Within a large group of more than 700 patients treated with CAR T cell therapy, researchers found no evidence that the therapy itself caused any type of secondary cancer in the modified T cells, according to new analysis reported
