A global consensus on physical exercise establishes the keys to healthy longevity in older adults.

With increasing life expectancy, a key question arises: how can we live longer without losing quality of life? The Global Consensus on Optimal Exercise Recommendations to Enhance Healthy Longevity in Older Adults offers a resounding answer: physical exercise is not a supplement, but a pillar of treatment. Backed by decades of research and the collaboration

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FDA clears IND for clinical trial testing switchable CAR-T therapy in patients with autoimmune diseases, without chemotherapy

Innovative cellular therapy has potential to treat patients with lupus, systemic sclerosis, myositis and RA without chemotherapy-induced immune suppression. Calibr-Skaggs Institute for Innovative Medicines, the drug discovery division of Scripps Research, announced today that the FDA has cleared their investigational new drug (IND) application to study switchable chimeric antigen receptor T cell (sCAR-T) therapy (CLBR001

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University of Florida researchers identify safer pathway for pain relief

University of Florida scientists have helped identify a novel drug compound that selectively activates pain-altering receptors in the body, offering a potentially safer alternative to conventional pain medications. In a new study published in Nature Communications, researchers describe how this drug compound provides pain relief without the dangerous side effects commonly associated with opioids administered to

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Innovative gene therapy developed to treat a rare and devastating genetic heart disease in young men

A CNIC team has designed a gene therapy-based treatment that could transform the approach to arrhythmogenic cardiomyopathy type 5 (ARVC5), a rare and fatal genetic disease that particularly affects young men. A team from the  National Center for Cardiovascular Research (CNIC) has developed an innovative gene therapy that could transform the treatment of arrhythmogenic cardiomyopathy type 5 (ARVC5),

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Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

A new study published in Nature Cardiovascular Research found that while carotid artery narrowing can lead to stroke in both men and women, the symptoms and plaque characteristics often differ between the sexes. Even though the main types of cells in the plaques are similar, important differences exist in the smaller structures within those cells. According to the World

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The Mediterranean diet and physical activity maintain bone health in older adults

Following a low-calorie Mediterranean diet and regular physical activity mitigates the decline in bone health in older adults with metabolic syndrome , especially women. These are the main conclusions of a study led by a research team from the Rovira i Virgili University (URV) published in the scientific journal JAMA Network Open. The study included 924 men and women

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Regular Salt Substitution with Added-potassium salt lowers Recurrent Stroke and Death risk

Large clinical trial shows that replacing regular salt with a sodium-potassium blend offers a simple, low-cost intervention for stroke patients A recent randomized clinical trial claims that salt substitutes are safe and effective over regular salt in terms of reducing the risk of recurrent stroke and death in patients with a history of stroke. The detailed

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Stephen Hauser and Andrea Ascherio Win Breakthrough Prize in Life Sciences for Role in Redefining MS

Stephen hauser and Andrea Ascherio have played a pivotal part in identifying the cause of multiple sclerosis, leading to a new generation of game-changing therapies. Neuro-immunologist Stephen Hauser, MD, whose maverick thinking transformed the treatment landscape for patients with multiple sclerosis (MS), has received the 2025 Breakthrough Prize in Life Sciences. Hauser, a UCSF professor of

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Major advances in the treatment of type 1 diabetes

Recent decades have seen a lot of progress in diabetes treatment. In a new study, Per-Ola Carlsson, Professor of Medical Cell Biology, has obtained promising results. “This is the first time anyone has succeeded in transplanting insulin-producing cells into another individual without immunosuppressive drugs,” he says. The treatment available for type 1 diabetes since the

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