Analysis looked for—and did not find—examples where the process of generating CAR T cells caused malignancy Within a large group of more than 700 patients treated with CAR T cell therapy, researchers found no evidence that the therapy itself caused any type of secondary cancer in the modified T cells, according to new analysis reported
A team of physicists at Tampere University has developed a groundbreaking method for detecting congestive heart failure with greater ease and precision than previously thought possible. This multidisciplinary study, involving both cardiologists and computational physicists, builds on the team’s earlier breakthroughs, for example, in predicting the risk of sudden cardiac death. Researchers at Tampere University
GLP-1 medications tied to decreased risk of dementia, addiction; increased risk of kidney, pancreas and gastrointestinal problems Demand for weight-loss medications sold under brand names such as Ozempic and Wegovy continues to surge, with a recent study reporting one in eight Americans has taken or is currently using the drugs to treat diabetes, heart disease
One of the Largest Studies of its Kind Finds Early Intervention with Iron Delivered Intravenously During Pregnancy is a Safe and Effective Treatment for Anemia Anemia during pregnancy is a common occurrence and often due to iron deficiency. It is a global public health problem, affecting an estimated 37 percent of pregnant individuals, according to
Novel research in cells and mice models has provided insight into the mechanisms that regulate trogocytosis, a process during which immune cells can exchange membrane-bound proteins. The study showed that chimeric antigen receptor cells (so-called CAR-T cells) could transfer tumour antigen-specific receptors to recipient T cells, and in doing so equipped the latter cells with tumour-targeting
New options make care faster, safer, and more accessible At a glance: Tuberculosis remains one of the top infectious disease killers worldwide, a challenge amplified by drug-resistant forms of the disease. Now, in a major step forward, an international clinical trial has found three new safe and effective drug regimens for tuberculosis that is resistant to
New research, with the caveat of a relatively short follow-up, adds to encouraging data showing an overall low risk of the development of thyroid cancer associated with glucagon-like peptide 1 receptor agonist (GLP-1 RA) treatment. However, a notably increased rate of thyroid cancer detections limited only to the first year after drug initiation — but
First Drug Approved in New Class of Non-Opioid Pain Medicines; Agency Continues to Take Steps to Support New Approaches for Pain Management the U.S. Food and Drug Administration approved Journavx (suzetrigine) 50 milligram oral tablets, a first-in-class non-opioid analgesic, to treat moderate to severe acute pain in adults. Journavx reduces pain by targeting a pain-signaling
The heart patch is produced from induced pluripotent stem cells derived heart muscle cells in a collagen hydrogel. Results from rhesus macaques provide solid ground for a first-in-human investigation of heart repair with stem cell-derived engineered heart muscle. The study is a milestone for the clinical application of the ‘heart patch’ as an innovative treatment
EPFL researchers have combined injections of a novel hydrogel with systemic osteoporosis drugs in rats, achieving rapid local increases in bone density. The results offer hope for future fracture prevention therapies in osteoporosis patients. Osteoporosis is a disease in which bone resorbs faster than it is formed, gradually weakening its structure over time and leading
