Archives: 2022-10-14

PIER MARIA FORNASARI
2022-10-14

Results of a phase 1 UCART19 trial, a first-in-class allogeneic anti-CD19 CART-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM) published in The Lancet Haematology

The prognosis for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia remains poor. UCART19, an allogeneic genome-edited anti-CD19 chimeric antigen receptor (CAR) T-cell product derived from healthy donors and available for immediate clinical use, offers a potential therapeutic option for such patients. The CALM trial is a first-in-human study evaluating the safety and antileukaemic

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No Comments InCAR-T
PIER MARIA FORNASARI
2022-10-11

SARS-CoV-2 origin: the evidence towards zoonosis is overwhelming: experts panel conclusions in PNAS. One Health approach is necessary to diminish zoonosis threats.

“Smart surveillance” for viral spillover from animals to humans, targeted preparedness and drug and vaccine research, and worldwide cooperation on surveillance and stopping disease spread are required to reduce deaths and lessen the economic consequences of the next pandemic, according to an international team of scientists. In a perspective article published this week in Proceedings of

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No Comments InCovid-19
PIER MARIA FORNASARI
2022-10-11

XBB, SARS CoV-2 variant detected in Singapore and Hong Kong, is significantly more immune evasive than BA.2.75.2 and BQ.1.1 

A fantastic diagram by Daniele Focosi showing the convergent evolution that has led to the lineages we have been discussing recently, including BQ.1.1, CA.1, BR.2 and the new XBB variant. The speed with which SARS-CoV-2 is now evolving is quite breathtaking – ever-fitter variants are now being uncovered on an almost daily basis. Just over one week

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No Comments InCovid-19
PIER MARIA FORNASARI
2022-10-10

Colonoscopy unfortunately is not a miracle cure for colorectal cancer. According to study published inNEJM is not better than the fecal samples

On October 10 the world’s first randomized study on using colonoscopy-screening to prevent colorectal cancer was presented during the 2022 United European Gastroenterology Week in Vienna. The full study was also published in New England Journal of Medicine. “Colonoscopy unfortunately is not a miracle cure for colorectal cancer. According to our study, it probably is not better

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No Comments InRESEARCH
PIER MARIA FORNASARI
2022-10-10

A comprehensive SARS-CoV-2–human protein–protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets: a Cleveland Clinic study finds.

A Cleveland Clinic-led research team used artificial intelligence to map out hundreds of ways that the virus that causes COVID-19 interacts with infected cells. Through this analysis, they identified potential COVID-19 medicines within thousands of drugs already approved by the FDA for other treatments. The research focused on host-targeting therapies, which operate differently from other

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No Comments InCovid-19
PIER MARIA FORNASARI
2022-10-10

Gene Therapy Rapidly Improves Night Vision in Adults with Congenital Blindness, Penn Study Finds

Patients’ low-light sensitivity improved by factors of thousands in a clinical trial Adults with a genetic form of childhood-onset blindness experienced striking recoveries of night vision within days of receiving an experimental gene therapy, according to researchers at the Scheie Eye Institute in the Perelman School of Medicine at the University of Pennsylvania. The patients

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No Comments InGENE THERAPY RARE DISEASES
PIER MARIA FORNASARI
2022-10-10

Estimated Global Proportions of Individuals With Persistent Fatigue, Cognitive and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021

Women and people who needed to be hospitalized with Covid are much more likely to develop long Covid, according to a new peer reviewed study published in JAMA on Monday, offering new insight into the persistent and sometimes disabling condition as researchers push to develop new treatments and cures. KEY FACTS An estimated 6% of people with symptomatic Covid infections develop

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No Comments InCovid-19