Archives: 2022-11-22

CAR T-Cell Therapies in Relapsed/Refractory Multiple Myeloma

The increasing integration of CAR T-cell therapies into the treatment paradigm for adult patients with relapsed or refractory multiple myeloma addresses several unmet needs and improves outcomes for this historically limited patient population. The increasing integration of CAR T-cell therapies into the treatment paradigm for adult patients with relapsed or refractory multiple myeloma addresses several

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Association of National Football League Fan Attendance With County-Level COVID-19 Incidence in the 2020-2021 Season

A study of National Football League (NFL) home games attended by 1.3 million fans suggests that those with high attendance were tied to subsequent county-level COVID-19 surges during the 2020-2021 season. A team led by a University of Southern Mississippi researcher analyzed data from all 32 NFL teams during the 2020-2021 season, when some games were open

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Comparative Risk of Thrombosis With Thrombocytopenia Syndrome or Thromboembolic Events Associated With Different COVID-19 Vaccines published in BMJ

OBJECTIVE To quantify the comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with use of adenovirus based covid-19 vaccines versus mRNA based covid-19 vaccines. DESIGN International network cohort study. SETTING Routinely collected health data from contributing datasets in France, Germany, the Netherlands, Spain, the UK, and the US. PARTICIPANTS Adults (age ≥18

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Cleveland Researchers Discover New Oral Drug for Lowering Cholesterol

Study led by University Hospitals and Case Western Reserve University team details a small-molecule drug that lowers cholesterol by 70% in animal models –After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are

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Research brief by Minnesota University: Association between diabetes medication and less severe cases of COVID-19

Published in PLOS ONE, a study led by the University of Minnesota Medical School studied adults with type 2 diabetes who were taking metformin, a commonly prescribed diabetes medication. Researchers found an association with less severe cases of COVID-19 for those prescribed metformin. These findings were part of an observational study that analyzed electronic medical

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Real-world evidence study of regenerative medicine and shoulder surgery

Applying regenerative medicine to a common shoulder surgery could have an impact on the need for follow-up revision surgery in some patients, according to a Mayo Clinic study of real-world evidence. Mayo Clinic researchers analyzed the largest set of data available to determine if adding bone marrow aspirate concentrate to repaired tissue after standard rotator cuff surgery would improve

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Anti-Vax Doctor Simone Gold Sued by America’s Frontline Doctors, the Group She Founded: misused the organization’s funds to buy a $3.6 million Florida mansion, purchase a Mercedes-Benz and other luxury vehicles, and take trips on private planes.

Source: Medscape America’s Frontline Doctors is suing one of its founders in a battle for control over the controversial group, which gained national notoriety for spreading misinformation about COVID-19 treatments and vaccines during the pandemic. The organization and its current board chairman have sued Simone Gold, MD, alleging that she misused the nonprofit organization’s funds

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Glucose metabolites, rather than glucose itself, have been discovered to be key to the progression of type 2 diabetes.

Oxford Research reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes.  In diabetes, the pancreatic beta-cells do not release enough of the hormone insulin, which lowers blood glucose levels. This is because a glucose metabolite damages pancreatic beta-cell function. An estimated 415 million people globally are living with diabetes. With nearly 5

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