Cognitive impairment as a result of severe COVID-19 is similar to that sustained between 50 and 70 years of age and is the equivalent to losing 10 IQ points, say a team of scientists from the University of Cambridge and Imperial College London. Cognitive impairment is common to a wide range of neurological disorders, but
Chimeric antigen receptor T-cell therapy, or CAR T, has made a big impact on the treatment of certain blood cancers, allowing patients with relapsed/refractory disease to live longer, healthier lives. But in clinical study, the cellular therapy has not been as successful for patients with solid tumors, due in part to the lack of tumor
Researchers have discovered the blood clotting and immune protein pathways that are activated in severe cases of COVID-19 in children, paving the way for earlier diagnosis and more targeted treatments. The study led by the Murdoch Children’s Research Institute (MCRI) and the University of Melbourne and published in Nature Communications, has identified disease mechanisms in children with COVID-19
During October–November 2021, clinicians at a children’s hospital in Alabama identified five pediatric patients with severe hepatitis and adenovirus viremia upon admission. In November 2021, hospital clinicians, the Alabama Department of Public Health, the Jefferson County Department of Health, and CDC began an investigation. This activity was reviewed by CDC and conducted consistent with applicable
Graphical abstract showing how TALEDs work in mitochondria. First, adenine is deaminated to inosine. Next, inosine is converted to guanine by DNA repair or replication. Scientists successfully achieve A to G base conversion, the final missing piece of the puzzle in gene-editing technology Researchers from the Center for Genome Engineering within the Institute for Basic
A comprehensive tool that can assess the symptoms of Long COVID has been developed at the University of Birmingham for use in research and clinical care. Developed with patients that have lived experience of Long COVID, the tool can capture symptoms and their impact on everyday life. Currently more than 200 symptoms are associated with Long
If you have Covid-19 symptoms but test negative with a rapid antigen test, you should test again 1-2 days later, or on day four of feeling crook, new research suggests. A study out of the United States, conducted between January-May 2021 and published in JAMA Internal Medicine on Saturday, compared the PCR and RAT results of 225 children
The research group led by Professor Misao Fujita conducted a study to estimate the total amount of refund the Japanese government would pay if a patient received unproven cell interventions and applied for a medical expense deduction. Some regenerative medicines whose safety and efficacy have not been fully confirmed in clinical trials and other studies are offered
Key Takeaways Acute myeloid leukemia is the most common leukemia in adults. CAR T cell therapy has made significant inroads against leukemias and lymphomas arising from B cells, but have been largely ineffective against leukemias arising from myeloid cells. MGH investigators have devised a novel method for improving CAR T therapy through a drug combination
SARS-CoV-2 variants continue to be a topic of great concern. As weeks go by, it is evident that the Omicron family of viruses continue to grow in complexity. Figures one and two show the extent of variation from the beginning of the pandemic up to the present. Figure 1 roughly illustrates the complexity of SARS-CoV-2
