During the initial stages of cellular infection, SARS-CoV-2 releases a number of accessory proteins to help suppress and evade our immune system. ORF7a is one such protein. Suppression of the innate immune system is necessary for the virus to establish infection. The several-day suppression of the immune system by the virus also contributes to the
Mount Sinai study shows dramatic protective effects of vaccination in this high-risk population, which often demonstrates vaccine hesitancy Heart failure patients who are unvaccinated against SARS-CoV-2, the virus that causes COVID-19, are three times more likely to die if infected with the virus compared to fully boosted heart failure patients, according to new research out
The partisan divide in the United States throughout the COVID-19 pandemic has stretched beyond differences in attitudes about masking, social distancing and vaccines. According to a new study led by a University of Maryland researcher, it also is tied to a clear difference in mortality rates from the virus. In the study, published today in Health
A new study highlights how closely connected politics and health outcomes have grown over time. Investigators from Brigham and Women’s Hospital examined mortality rates and federal and state election data for all counties in the U.S. from 2001 to 2019. The team found what they call a “mortality gap” — a widening difference between age-adjusted death rates
Given recent progress in cell therapy research, it is clear that the engineering disciplines outlined in this Review will play an increasing role in the creation of new product pipelines with improved safety, efficacy and accessibility for patients. Recent scientific advances have not only demonstrated the potential impact of technologiesdeveloped by each of these fields,
Understanding how a type of white blood cell called a neutrophil behaves at the site of a tissue injury might one day lead to advances in wound repair and inflammation, said Dr. Anna Huttenlocher, at the first in-person NIH Director’s Wednesday Afternoon Lecture in Lipsett Amphitheater since March 2020. Known as the immune system’s first
Stanford researchers modified anti-cancer CAR-T cells so they can be controlled with an oral drug. The modified cells are safer, more potent and more active against solid tumors in mice. A cancer treatment that uses a patient’s own genetically modified immune cells to attack cancer cells is safer and more effective when it can be
In a retrospective study based on big data, the researchers found that Leukotriene Inhibitors (LTI)s prevented death in COVID-19 patients with low oxygen saturation University at Buffalo biomedical informatics researchers have found that patients hospitalized with COVID-19 pneumonia had a 13.5% survival advantage when treated with a combination of leukotriene inhibitors (LTIs) and the steroid
While risks higher for the unvaccinated, study points to need for more tools against the virus Vaccinated people with mild breakthrough COVID-19 infections can experience debilitating, lingering symptoms that affect the heart, brain, lungs and other parts of the body, according to researchers at Washington University School of Medicine in St. Louis and the Veterans
Scientists from the University of Birmingham have shown an existing drug may reduce damage after spinal cord injury, by blocking the inflammatory response in the spinal cord. Their research, published today in Clinical and Translational Medicine, demonstrates that AZD1236, a drug developed by AstraZeneca, can significantly reduce “secondary damage” caused by the body’s response to spinal
