Today, the U.S. Food and Drug Administration approved Hemgenix (etranacogene dezaparvovec), an adeno-associated virus vector-based gene therapy for the treatment of adults with Hemophilia B (congenital Factor IX deficiency) who currently use Factor IX prophylaxis therapy, or have current or historical life-threatening hemorrhage, or have repeated, serious spontaneous bleeding episodes. “Gene therapy for hemophilia has
Infection with the pandemic virus, SARS-CoV-2, can reduce the number of bacterial species in a patient’s gut, with the lesser diversity creating space for dangerous microbes to thrive, a new study finds. The study builds on the realization that widespread use of antibiotics to fight infections with disease-causing bacteria in recent decades, by killing off
Covid-19 can negatively impact short-term memory function, the results of a new study have revealed. The researchers say memory function can recover over time, but those with ongoing Covid symptoms may continue to experience difficulties. The team, from Hull York Medical School, used an online anonymous survey which included a memory quiz that could be completed
The increasing integration of CAR T-cell therapies into the treatment paradigm for adult patients with relapsed or refractory multiple myeloma addresses several unmet needs and improves outcomes for this historically limited patient population. The increasing integration of CAR T-cell therapies into the treatment paradigm for adult patients with relapsed or refractory multiple myeloma addresses several
A study of National Football League (NFL) home games attended by 1.3 million fans suggests that those with high attendance were tied to subsequent county-level COVID-19 surges during the 2020-2021 season. A team led by a University of Southern Mississippi researcher analyzed data from all 32 NFL teams during the 2020-2021 season, when some games were open
OBJECTIVE To quantify the comparative risk of thrombosis with thrombocytopenia syndrome or thromboembolic events associated with use of adenovirus based covid-19 vaccines versus mRNA based covid-19 vaccines. DESIGN International network cohort study. SETTING Routinely collected health data from contributing datasets in France, Germany, the Netherlands, Spain, the UK, and the US. PARTICIPANTS Adults (age ≥18
Study led by University Hospitals and Case Western Reserve University team details a small-molecule drug that lowers cholesterol by 70% in animal models –After statins, the next leading class of medications for managing cholesterol are PCSK9 inhibitors. These highly effective agents help the body pull excess cholesterol from the blood, but unlike statins, which are
Scientists discuss what may come next as SARS-CoV-2 evolves and why COVID-19 won’t be our last pandemic As SARS-CoV-2 seems to settle into the background of our lives, transitioning from an unprecedented crisis to a routine threat alongside influenza and other, more familiar viruses, scientists have begun to turn their attention to the future of
Published in PLOS ONE, a study led by the University of Minnesota Medical School studied adults with type 2 diabetes who were taking metformin, a commonly prescribed diabetes medication. Researchers found an association with less severe cases of COVID-19 for those prescribed metformin. These findings were part of an observational study that analyzed electronic medical
Applying regenerative medicine to a common shoulder surgery could have an impact on the need for follow-up revision surgery in some patients, according to a Mayo Clinic study of real-world evidence. Mayo Clinic researchers analyzed the largest set of data available to determine if adding bone marrow aspirate concentrate to repaired tissue after standard rotator cuff surgery would improve
