Archives: 2019-10-16

Scientists at the MDI Biological Laboratory Are Decoding the Genetic Mechanisms of Aging and the Role of Dietary Restriction

Discoveries Could One Day Lead to New Drugs to Prolong Healthy Human Lifespan The discovery in the 1990s that a mutation in a single gene of an experimental worm could double its lifespan set off a stampede of research on the molecular biology of aging and triggered hopes that drug therapies or other interventions could

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Cell family trees tracked to discover their role in tissue scarring and liver disease

Researchers have discovered that a key cell type involved in liver injury and cancer consists of two cellular families with different origins and functions. The research by academics from the Universities of Edinburgh and Bristol and funded by the Wellcome Trust and Medical Research Council, is published today [Tuesday 15 October] in Nature Communications. The distinguishing

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Novel deep-learning approach for predicting and explaining the key prognostic factors for patients with Mesothelioma

Owkin publishes breakthrough research in Nature Medicine Owkin, which is developing machine learning technologies to advance medical research, today announces publication of a paper in Nature Medicine that showcases its breakthrough analysis of tumour biology using interpretable deep-learning models. The paper entitled ‘Deep learning-based classification of mesothelioma improves prediction of patient outcomes’ describes how Owkin

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Geneticists retract study suggesting first CRISPR babies might die early

Researchers rapidly corrected finding through discussions on social media and preprints. Source Nature A study that raised questions over the future health of the world’s first gene-edited babies has been retracted because of key errors that undermined its conclusion. The research, published in June 2019 in Nature Medicine1, had suggested that people with two copies of a natural genetic mutation

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Mila’s N-of-1 Trial Detailed in NEJM

Neurologic scores stabilized, seizures diminished with tailored antisense oligonucleotide therapy The researchers who developed a personalized antisense oligonucleotide (ASO) for a little girl with a form of Batten disease — all in record time — have detailed their case in the New England Journal of Medicine. Timothy Yu, MD, PhD, of Boston Children’s Hospital, and colleagues explained how

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