Source Trends in Molecular Medicine Mitochondria and lysosomes are pivotal organelles for cellular metabolism and also have important roles as signaling platforms. Many diseases are characterized by impaired mitochondrial or lysosomal function. These are often referred to as ‘mitochondrial diseases’, which have a primary cause in mitochondria, or as lysosomal storage diseases. Although each specific
Multinozzle printer can switch between multiple inks up to 50 times per second 3D printers are revolutionizing manufacturing by allowing users to create any physical shape they can imagine on-demand. However, most commercial printers are only able to build objects from a single material at a time and inkjet printers that are capable of multimaterial
High-throughput synthetic biology approach reveals hidden AAV features and could help fast-track future gene therapies Adeno-associated viruses (AAVs) have become the go-to vehicle for delivering therapeutic gene cargo to target tissues for the wave of gene therapies that are in development in academic and biotechnology laboratories. However, natural AAVs do not specifically target diseased cells
For the first time, The Arthroscopy Association of North America (AANA), the American Orthopaedic Society for Sports Medicine (AOSSM), the International Cartilage Repair Society (ICRS) and the ON Foundation have collaborated to form The Biologics Alliance (BA)™, an orthopaedic organization dedicated to providing one voice for all matters on musculoskeletal biologics and regenerative medicine. Recently, randomized clinical trials and clinical practice guidelines
Funds paved the way for rigorous tests of therapies, but unintentionally boosted a market for potentially dangerous fakes, says Jeanne F. Loring. Source Nature For the past dozen or so years, stem-cell researchers in California have been the envy of the world. In 2004, as a rebuke to the restrictions put in place in the
New data released shows cell and gene therapy manufacturing facilities are rapidly becoming operational reflecting job expansion in the sector. Additional 6,000m2 of cell and gene therapy manufacturing space expected to become available within the next 12 months. The Cell and Gene Therapy Catapult (CGT Catapult) published the sixth annual UK cell and gene therapy
Researchers were able to apply a machine-learning computational model to arrange stem cells into different shapes. The holy grail of medical advancements is being able to create organs out of one’s own cells. But to do that researchers have to organize stem cells into predictable patterns, which has been quite a struggle. 3-D printing is one approach
A novel bioink can integrate living cells into 3D scaffolds at a speed of one meter per second, making it possible to study the spread of diseases and produce tailor-made tissue. 3D bioprinting has come a long way in recent years, with scientists using living tissue to print organs as complex as human skin. Researchers in
Google has gained access to a huge trove of US patient data – without the need to notify those patients – thanks to a deal with a major health firm. The scheme, dubbed Project Nightingale, was agreed with Ascension, which hopes to develop artificial intelligence tools for doctors. Google can access health records, names and
Liquid-in-liquid 3D printing was first presented in a BMW funded MIT project. Although the project initially seemed limited in scope the possibilities of 3D printing within a liquid medium opens new opportunities in terms of escaping gravitational pull and thus producing parts that require a more volumetric approach, such as biological structures and organs. As reported
