New research has observed that the benefits of CAR-T cell immunotherapies – for the treatment of diseases such as pediatric acute lymphoblastic leukemia and diffuse large B-cell lymphoma – may be offset by their delayed delivery to patients. The social value of a therapy balances manufacturer costs and profits versus a patient’s improvement in quality-adjusted
The vision is ambitious : Enroll 1 million people in the NIH’s All of Us Research program, whose goal is to make personalized medicine a reality for everyone. That means ensuring that more than half of participants come from communities historically underrepresented in biomedical research. A year after its launch, 230,000 people have joined, 80% of
Countries that relax regulations for regenerative medicines could be causing a downward spiral in international standards, according to new research published today. Researchers warn that if just one country decides to relax regulations in the field, a heightened sense of competition can spur others to do the same. It’s unclear whether this deregulation best serves
It has taken some time in finally getting its official launch, but government has opened the doors to a new public-private research hub aimed at using new digital technologies to build products and services to help keep elderly people in their own homes for longer. The Research Hub for Digital Enhanced Living being housed at Deakin University aims
Nanotechnology developed at Rutgers University-New Brunswick could boost research on stem cell transplantation, which may help people with Alzheimer’s disease, Parkinson’s disease, other neurodegenerative diseases and central nervous system injuries. The nanotechnology platform, which uses special tiny rods for sensing, allows researchers to confirm the identity of human stem cell fates and their biomarkers, or
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. Researchers at UCLA recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs) and describe small molecule inhibitors of PTPσ that promote HSC regeneration in vivo. Systemic administration of the PTPσ inhibitor, DJ001, or its analog, to
Source STAT A common saying at the Food and Drug Administration is: “In God we trust, all others must bring data.” The independent evaluation of science is an essential element of the FDA’s dual role of protecting the public health and promoting innovation to bring new therapies into practice. In fact, with certain exceptions, the
New research reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem cells to a younger, healthier state. New research, published today in Nature, reveals how increasing brain stiffness as we age causes brain stem cell dysfunction, and demonstrates new ways to reverse older stem
The results of an early trial in 31 brain cancer patients finds immune activity boosted in the tumor, and possibly longer survival. An inducible, tumor-localized gene therapy has been tested for the first time in glioblastoma patients. The two-part approach, which involves receiving an injection of an immune-activator gene into the brain tumor site and
A Novel Hypothesis: The Microbiota–Gut–Brain Axis The two most common neurodegenerative disorders have a very long history. The first reported case of Alzheimer’s disease (AD) was in 1906, while Parkinson’s disease (PD) was described in 1817. Since then, intensive research has provided plenty of clinical, genetic, and molecular evidence of AD and PD signs, mechanisms,
